Klinički i laboratorijski nalazi kod pasa otrovanih antikoagulansima

master's thesis

• Title (english): Clinical and laboratory findings in dogs with anticoagulant poisoning
• Author: Hrvoje Tušek
• Mentor: Ivana Kiš (mentor)
• Mentor: Iva Mayer (komentor)
• Committee member: Vesna Matijatko
• Committee member: Iva Mayer
• Committee member: Ivana Kiš
• Granter: University of Zagreb; Faculty of Veterinary Medicine; (Internal Diseases Clinic); Zagreb
• Defense date and country: 2015, Croatia
• Scientific / art field, discipline and subdiscipline: BIOMEDICINE AND HEALTHCARE; Veterinary Medicine; Veterinary Clinical Sciences

Abstract

U naše istraživanje bila su ukljucena 22 psa, 12 mužjaka i 10 ženki, za koje je pregledom
arhive Klinike za unutarnje bolesti utvrdeno da im je dijagnosticirano trovanje
antikoagulacijskim rodenticidima na temelju anamneze, klinickog pregleda, rendgenskog
nalaza te koagulacijskih pretraga krvi (PV i APTV).
Najcešci osnovni simptom trovanja bilo je krvarenje i utvrdeno je u 59% pasa. U 18%
pasa utvrdena je dispneja, konvulzije i inapetenca bili su prisutni u 9% slucajeva, a depresija u
5% životinja.
U 59% pasa temperatura, bilo i disanje bili su povišeni, dok su u 7% njih bile povišene
samo vrijednosti bila i disanja, uz fiziološke vrijednosti temperature. U 9% pasa su
vrijednosti temperature, bila i disanja bile unutar fizioloških granica.
Statisticki obradeni rezultati rendgenskog nalaza su pokazali da je u 50% životinja
utvrden likvidotoraks, u 18% likvidoperitoneum, dok je hidroperikard utvrden u 9% pasa. U
23% slucajeva rendgenski nalaz je bio negativan. Kod pasa kod kojih je rendgenskom
pretragom utvrden likvidotoraks punkcijom je potvrden hemotoraks, a hemoperitoneum kod
pasa kod kojih je utvrden hidroperitoneum. U pasa u kojih je rentgenskom pretragom
dijagnosticiran hidroperikard, punkcijom je potvrden hemoperikard.
Usporedujuci rezultate hematoloških pretraga sa referentnim vrijednostima utvrdili smo
da su srednja vrijednost broja eritrocita i srednja vrijednost hematokrita bili sniženi, dok je
srednja vrijednost broja trombocita bila unutar fizioloških granica.
Rezultati biokemijskih pretraga su pokazali da je srednja vrijednost ureje bila iznad, a
srednja vrijednost kreatinina unutar fizioloških granica. Srednja vrijednost ukupnih proteina te
albumina bila je neznatno ispod donje fiziološke granice, dok je srednja vrijednost kreatinin
fosfokinaze bila znatno iznad fizioloških granica.

Abstract (english)

Our study included 22 dogs, 12 males and 10 females, the retrospective review of medical
records of Clinic for internal diseases has revealed they were diagnosed with anticoagulant
poisoning through history, clinical examination, roentgenological findings and coagulation
tests (PT and APTT).
The most common main symptom of the poisoning was bleeding and it was found in 59%
of dogs. 18% of dogs had dyspnea, while convulsions and inappetence were present in 9% of
cases and depression in 5 % of animals.
In 59% of dogs the temperature, heart rate and respiration rate were increased, while in
7% of dogs the values of heart rate and respiration rate were increased but the temperature
was within normal limits. In 9% of dogs the temperature, heart rate and respiration rate were
within physiological values.
Statistically processed results of the roentgenological findings have shown that
liquidothorax was found in 50% and liquidoperitoneum in 18% of animals, while
hydropericard was found in 9 % of dogs. In 23% of cases roentgenological findings were
negative. After the aspiration, haemothorax was confirmed in dogs with liquidothorax,
haemoperitoneum in dogs with liquidoperitoneum and haemopericard in dogs with
hydropericard.
Comparing the results of haematological tests with physiological values, the mean value
of the number of erythrocytes and the mean value of hematocrit were below physiological
values, while the mean value of the number of thrombocytes was within the physiological
values.
The results of biochemical tests have shown that the mean value of urea was above and
the mean value of creatinine was within normal limits. The mean values of total proteins and
albumins were slightly below lower physiological limit and the mean value of creatinin
phosphokinase was extremely above phisiological limits.

• Keywords: pas; trovanje; antikoagulansi; klinicki nalaz; laboratorijski nalaz
• Keywords (english): dog; poisoning; anticoagulants; clinical findings; laboratory findings
• Language: croatian
• URN:NBN: urn:nbn:hr:178:913975
• Study programme: Title: Veterinary Medicine; Study programme type: university; Study level: integrated undergraduate and graduate; Academic / professional title: doktor/doktorica veterinarske medicine (doktor/doktorica veterinarske medicine)
• Type of resource: Text
• File origin: Born digital
• Access conditions: Access restricted to students and staff of home institution
• Created on: 2016-01-18 14:00:30