OSTEOARTROZA U MAČAKA - DIJAGNOSTIKA, TERAPIJA I REHABILITACIJA

master's thesis

• Title (english): Osteoarthritis in cats - diagnosis, therapy and rehabilitation
• Author: Lea Brumnić
• Mentor: Zoran Vrbanac (mentor)
• Mentor: Valentina Plichta (mentor)
• Committee member: Hrvoje Capak (predsjednik povjerenstva)
• Committee member: Zoran Vrbanac (član povjerenstva)
• Committee member: Valentina Plichta (član povjerenstva)
• Committee member: Andrija Musulin (član povjerenstva)
• Granter: University of Zagreb; Faculty of Veterinary Medicine; Zagreb
• Defense date and country: 2023-01, Croatia
• Scientific / art field, discipline and subdiscipline: BIOMEDICINE AND HEALTHCARE; Veterinary Medicine; Veterinary Clinical Sciences

Abstract

Osteoartritis je vrlo često upalno stanje u mačaka starijih od 12 godina, a najnovija
istraživanja pokazuju da se OA radiografski često dijagnosticira i kod mlađih mačaka. OA je
poremećaj na razini organa, kroničnog je tijeka te polagano progredira. U nastanku same bolesti
veliku ulogu imaju biomehanički i genetski čimbenici, dok je nastanak upale povezan sa
progresijom bolesti i degradacijom hrskavice. Stanice unutar oštećenih zglobova otpuštaju
protupalne citokine koji pojačavaju i produljuju upalni proces. Bolest zahvaća cijeli zglob i okolne
strukture. Životinje otežano ustaju, šepaju, pokazuju znakove boli te je vidljiva smanjena
pokretljivost zglobova. Jednom kad se postavi dijagnoza putem općeg kliničkog pregleda,
ortopedskog i neurološkog pregleda te RTG metode, dva su cilja terapije: uklanjanje boli i očuvanje
funkcije zgloba. Liječenje se temelji na multimodalnoj terapiji kojoj je cilj smanjenje upale,
smanjenje boli u zglobu te smanjenje funkcionalne nesposobnosti. Dostupno je mnogo lijekova
protiv bolova, uključujući nesteroidne protuupalne lijekove i opioide. Također, regulacija tjelesne
težine i nutritivna potpora zglobovima važni su aspekti liječenja OA. Konačno, fizikalna
rehabilitacija izvrstan je način za poboljšanje mobilnosti i olakšavanja svakodnevnih aktivnosti
kućnih ljubimaca. Rana dijagnostika i aktivno praćenje stanja životinje mogu poboljšati kvalitetu
života mačaka koje pate od bolova i smanjene pokretljivosti povezanih s osteoartritisom.

Abstract (english)

Osteoarthritis is a very common inflammatory condition in cats over 12 years of age, and
the latest research shows that OA is often diagnosed radiographically in younger cats as well. It is
a disorder at the organ level disorder , it is chronic and progresses slowly. Biomechanical and
genetic factors play a role in the development of the disease itself, while the development of
inflammation is associated with disease progression and cartilage degradation. Cells inside
damaged joints release pro-inflammatory cytokines that intensify and prolong the inflammatory
process. The disease affects the entire joint and surrounding structures. Animals have difficulties
standing up and the limp, they show signs of pain and visibly reduced joint mobility. Once a
diagnosis is established through a general clinical examination, orthopedic and neurological
examination, and X-ray methods, the two goals of therapy are pain relief and functional
preservation. The treatment is based on multimodal therapy, the goal of which is to reduce
inflammation, reduce pain in the joint, and reduce functional disability. A variety of pain relievers
are available, including NSAID opioids. Also, weight management and nutritional joint support
are important aspects of OA treatment. Finally, physical rehabilitation is a great way to improve
mobility and keep pets active. Early diagnosis and active monitoring of the animal's condition can
improve the quality for life of cats suffering from pain and reduced mobility associated with
osteoarthritis.

• Keywords: osteoartritis; citokini; zglobna hrskavica; rendgenska dijagnostika; multimodalna terapij
• Keywords (english): osteoarthritis; cytokines; articular cartilage; radiological diagnosis; multimodal therapy
• Language: croatian
• URN:NBN: urn:nbn:hr:178:360709
• Study programme: Title: Veterinary Medicine; Study programme type: university; Study level: integrated undergraduate and graduate; Academic / professional title: doktor/doktorica veterinarske medicine (doktor/doktorica veterinarske medicine)
• Type of resource: Text
• File origin: Born digital
• Access conditions: Open access
• Created on: 2023-02-07 08:59:11