DOSADAŠNJE SPOZNAJE O POVEZANOSTI REŽIMA PREHRANE I POJAVE DILATATIVNE KARDIOMIOPATIJE (DCM) KOD PASA

master's thesis

• Title (english): CURRENT KNOWLEDGE OF DIET REGIMEN AND DEVELOPMENT OF DILATATIVE CARDIOMYOPATHY (DCM) IN DOGS
• Author: Stipe Hobar
• Mentor: Hrvoje Valpotić (mentor)
• Committee member: Diana Brozić (predsjednik povjerenstva)
• Committee member: Tomislav Mašek (član povjerenstva)
• Committee member: Hrvoje Valpotić (član povjerenstva)
• Committee member: Željko Mikulec (član povjerenstva)
• Granter: University of Zagreb; Faculty of Veterinary Medicine; Zagreb
• Defense date and country: 2023-07, Croatia
• Scientific / art field, discipline and subdiscipline: BIOMEDICINE AND HEALTHCARE; Veterinary Medicine; Animal Production and Biotechnology

Abstract

Nastanak dilatativne kardiomiopatije (DCM) se posljednjih 5 godina sve više povezuje
s režimom prehrane koji u sebi sadrži mahunarke i krumpir. Glavnim čimbenikom te poveznice
smatra se deficit taurina, nesencijalne aminokiseline koja sadrži sumpor i koju psi mogu
endogeno sintetizirati. U namirnicama poput graška, leće, slanutka, količina prekursora taurina,
aminokiselina metionina i cisteina, nije dovoljna, te posljedično tome može doći do deficita
taurina i moguće pojave dilatativne kardiomiopatije. U velikih i gigantskih pasmina pasa, zbog
smanjene sinteze taurina preporučuje se njegova suplementacija. Također deficiti nutrijenata
poput karnitina, vitamina E, selena bakra, tiamina, ali i konzumacija hrane s visokim udjelom
vlakana se povezuju s mogućim nastankom nutritivnog oblika DCM-a. Prema analizi Američke
agencije za hranu i lijekove (FDA) velika većina pasa oboljelih od DCM-a konzumirala je suhu
hranu koja u sebi nije sadržavala žitarice, a sadržavala je grašak i leću, što nam ukazuje na
moguću poveznicu između pojedinih prehrana i nastanka DCM-a. Brojnim istraživanjima, u
kojima se promjenom režima hranidbe u životinja oboljelih od DCM-a s netradicionalnog u
tradicionalni, utvrdila su se poboljšanja u ehokardiografskom prikazu srca i sistoličkoj funkciji
srca, smanjenju koncentracije srčanih biomarkera u krvi, te produženom srednjem vremenu
preživljavanja. Zbog aktualnosti ove teme potrebna su daljnja istražvanja kako bi sa sigurnošću
mogli povezati ove režime prehrane s nastankom DCM-a.

Abstract (english)

Development of dilatative cardimyopathy (DCM) in the last 5 years has been more and
more connected with the diet regimen that contains pulse ingredients and potatoes. Main factor
of that connection was taurine deficiency, dispensable sulfur-containing amino acid that can be
endogenously synthesized in the dogs liver. Ingredients like peas, lentils, chickpeas do not
contain sufficient amount of amino acids methionine and cysteine, precursors of taurine
Consequence of that could be taurine deficiency and development of dilatative cardiomyopathy
In big and giant dog breeds supplementation of taurine should be recommended as the taurine
synthesis in these dogs is much lower. Deficiency in nutrients such as carnitine, vitamin E
selenium, tiamine or consumation of high fibre diet could also be connected with diet induced
DCM. According to the FDA analysis most of the dogs with DCM were fed with dry food tha
was grain free and contained peas and lentils, which could indicate the connection between
different diets and development of DCM. Numerous studies were made in which the positive
effects of diet change from nontraditional to traditional on echocardiographic assesment and
systolic function of the heart, alongside improvement of concentration of cardiac biomarkers in
blood and median survival rate were observed. Because this is currently a new topic, more
studies are necessary if we want to get more understading of connection between diet regimen
and development of DCM.

• Keywords: dilatativna kardiomiopatija; režim prehrane; mahunarke; taurin
• Keywords (english): dilatative cardiomyopathy; diet regimen; pulses; taurine
• Language: croatian
• URN:NBN: urn:nbn:hr:178:339533
• Study programme: Title: Veterinary Medicine; Study programme type: university; Study level: integrated undergraduate and graduate; Academic / professional title: doktor/doktorica veterinarske medicine (doktor/doktorica veterinarske medicine)
• Type of resource: Text
• File origin: Born digital
• Access conditions: Open access
• Created on: 2023-07-20 08:45:23