Tumori središnjeg živčanog sustava u pasa

master's thesis

• Title (english): Tumors of Central Nervous System in Dogs
• Author: Mateja Šmic
• Mentor: Lidija Medven Zagradišnik (mentor)
• Committee member: Andrea Gudan Kurilj (predsjednik povjerenstva)
• Committee member: Dunja Vlahović (član povjerenstva)
• Committee member: Lidija Medven Zagradišnik (član povjerenstva)
• Granter: University of Zagreb; Faculty of Veterinary Medicine; Zagreb
• Defense date and country: 2024-09-11, Croatia
• Scientific / art field, discipline and subdiscipline: BIOMEDICINE AND HEALTHCARE; Veterinary Medicine; Veterinary Clinical Sciences

Abstract

Glavnina primarnih tumora SŽS-a u pasa javlja se u dobi iznad pet godina
starosti. Meningeomi su najčešći primarni tumori mozga u pasa sa znatno većom
učestalosti u boksera, zlatnih retrivera, dugoglakih škotskih ovčara, minijaturnih
šnaucera, škotskih terijera te dolicefaličnih pasmina pasa. Astrocitomi su, nakon
meningeoma, drugi po učestalosti najčešći tumori SŽS-a; potom slijede
oligodendrogliomi koji čine do 15% svih primarnih tumora SŽS-a u pasa. Kao
zajedničko obilježje tumora glijalnog porijekla, navodi se povećana učestalost u
pojedinih brahiocefaličnih pasmina (bokser, buldog, bostonski terijer). Do 10% svih
primarnih tumora SŽS-a čine tumori koroidnog pleksusa, s većom pojavnosti u
pasmine zlatni retriver. Tumori SŽS-a u pasa s manjom učestalosti su redom
oligoastrocitomi (5%), ependimomi (3%) i embrionalni tumori s ukupnom učestalosti
<1%, dok se neuralni i miješani neuroglijalni tumori javljaju vrlo rijetko, s tek
nekoliko opisanih slučajeva u pasa. U neoplazme SŽS-a pasa rjeđe pojavnosti ubrajaju
se i ektopični nefroblastom torakolumbalnog dijela leđne moždine, tumori zrnatih
stanica, ali i meningeoangiomatoza koja predstavlja iznimno rijedak
meningovaskularan poremećaj. Histološka klasifikacija i gradacija tumora SŽS-a u
pasa preuzeta je iz humanog WHO sustava, a za konačnu potvrdu dijagnoze često je
nužna primjena imunohistokemijskih metoda.

Abstract (english)

The majority of primary CNS tumors in dogs occur at the age of five years or
older. Meningiomas are the most common primary brain tumors in dogs with a
significantly higher incidence in Boxers, Golden Retrievers, Long-eared Collies,
Miniature Schnauzers, Scottish Terriers and dolichocephalic dog breeds. Astrocytomas
are, after meningiomas, the second most common tumors of the CNS; followed by
oligodendrogliomas, which account for up to 15% of all primary CNS tumors in dogs.
As a common characteristic of tumors of glial origin, an increased frequency in certain
brachycephalic breeds (Boxer, bulldog, Boston Terrier) is mentioned. Up to 10% of all
primary tumors of the CNS are tumors of the choroid plexus, with a higher incidence
in Golden Retriever breeds. CNS tumors in dogs with lower frequency are respectively
oligoastrocytomas (5%), ependymomas (3%) and embryonal tumors with a total
frequency of <1%, while neural and mixed neuroglial tumors occur very rarely, with
only a few cases described in dogs . Neoplasms of the CNS of dogs of less frequent
occurrence include ectopic nephroblastoma of the thoracolumbar part of the spinal
cord, granular cell tumors, but also meningeoangiomatosis, which is an extremely rare
meningovascular disorder. The histological classification and grading of tumors of the
CNS in dogs is taken from the human WHO system, and for the final confirmation of
the diagnosis, the application of immunohistochemical methods is often necessary.

• Keywords: primarni tumori SŽS-a; pas; brahiocefalične pasmine; WHO klasifikacija; imunohistokemija
• Keywords (english): primary CNS tumors; dog; brachycephalic breeds; WHO classification; immunohistochemistry
• Language: croatian
• URN:NBN: urn:nbn:hr:178:863839
• Study programme: Title: Veterinary Medicine; Study programme type: university; Study level: integrated undergraduate and graduate; Academic / professional title: doktor/doktorica veterinarske medicine (doktor/doktorica veterinarske medicine)
• Type of resource: Text
• File origin: Born digital
• Access conditions: Open access
• Created on: 2024-10-17 12:25:34