Oftalmološke manifestacije meningoencefalitisa nepoznatog podrijetla kod pasa

master's thesis

• Title (english): Ocular manifestations of meningoencephalitis of unknown origin in dogs
• Author: Céline Sadaf Morteza Gholi
• Mentor: Valentina Plichta (mentor)
• Mentor: Ivana Kiš (mentor)
• Committee member: Ivan-Conrado Šoštarić-Zuckermann (predsjednik povjerenstva)
• Committee member: Valentina Plichta (član povjerenstva)
• Committee member: Martina Đuras (član povjerenstva)
• Granter: University of Zagreb; Faculty of Veterinary Medicine; Zagreb
• Defense date and country: 2024-12-13, Croatia
• Scientific / art field, discipline and subdiscipline: BIOMEDICINE AND HEALTHCARE; Veterinary Medicine; Veterinary Clinical Sciences

Abstract

Meningoencephalitis of unknown origin (MUO) is a general term describing
inflammatory changes of the central nervous system (CNS) for which non-infectious etiology
is assumed.
The purpose of this study is to examine the prevalence of ophthalmologic manifestations in
dogs diagnosed with MUO that were admitted to the Clinic for Internal Medicine and the Clinic
for Surgery, Ophthalmology and Orthopaedics of the Faculty of Veterinary Medicine of Zagreb.
Additionally, the study aims to assess both clinical and visual outcomes after the treatment of
these patients. The hypothesis was that ocular manifestations associated with MUO occur at a
relatively low incidence within the population of dogs affected by this condition.
In this study 10 patients from the faculty of Veterinary Medicine of Zagreb were
included. Prevalence of ocular clinical signs were a common feature since all the 10 patients
suffered from ophthalmological deficits. However, ocular clinical signs don’t necessarily mean
ocular form of GME. To distinguish these two: fundoscopy was performed on 4 out of the 10
patients and 3 patients had fundoscopic changes and were therefore considered as ocular form
of GME. They represent 30% of the sampled population. Considering that fundoscopy was not
performed in 6 of the sampled population, ocular form of GME can therefore be underestimated
in this study. However, the 3 patients with ocular form of GME had presence of multifocal
lesions thorough their CNS. Consequently, it is unlikely that these patients had the ocular form
of GME alone.
After the treatment, 80% of the patients survived to the date of writing this thesis. Among them
30% of the patients ended unilaterally blind, 20% ended up fully blind and 30% gained their
vision back.
MUO is a severe condition with a poor prognosis if not diagnosed promptly. Even when patients
survive, they are likely to experience lifelong sequelae.

Abstract (croatian)

Meningoencefalitis nepoznatog podrijetla (MNP) opći je izraz koji opisuje upalne
promjene središnjeg živčanog sustava (SŽS) za koje se pretpostavlja da imaju neinfektivnu
etiologiju.
Svrha ovog istraživanja je ispitati prevalenciju oftalmoloških manifestacija kod pasa
dijagnosticiranih s MNP, koji su primljeni na Kliniku za unutarnje bolesti i na Kliniku za
kirurgiju, oftalmologiju i ortopediju Veterinarskog fakulteta u Zagrebu. Osim toga, cilj je
procijeniti kliničke ishode nakon liječenja ovih pacijenata. Hipoteza je da se oftalmološke
manifestacije povezane s MNP pojavljuju s relativno niskom učestalošću unutar populacije
pasa pogođenih ovim stanjem.
U istraživanje je uključeno 10 pacijenata s Veterinarskog fakulteta u Zagrebu.
Oftalmološki klinički znakovi bili su česta značajka jer su svi pacijenti imali oftalmološke
deficite. Međutim, oftalmološki klinički znakovi ne znače nužno i očni oblik GME-a. Za
razlikovanje ovih stanja provedena je fundoskopija kod 4 od 10 pacijenata, pri čemu su kod 3
pacijenta zabilježene promjene na fundusu, što ih je svrstalo u kategoriju očnog oblika GMEa. Oni čine 30% ispitivane populacije. Budući da fundoskopija nije provedena kod 6
pacijenata, očni oblik GME-a u ovom istraživanju može biti podcijenjen. Međutim, kod 3
pacijenta s očnim oblikom GME-a zabilježena je prisutnost multifokalnih lezija u CNS-u, što
ukazuje da je malo vjerojatno da su imali isključivo očni oblik GME-a.
Nakon liječenja, 80% pacijenata preživjelo je do trenutka pisanja ovog rada. Među
njima, 30% pacijenata ostalo je slijepo na jedno oko, 20% potpuno slijepo, dok je 30%
povratilo vid.
MNP je ozbiljno stanje s lošom prognozom ako se ne dijagnosticira pravovremeno.
Čak i kad pacijenti prežive, često imaju trajne posljedice.

• Keywords: MUO; GME; Ocular; visual outcome.
• Keywords (croatian): MNP; GME; oftalmološki; vizualni ishod.
• Language: english
• URN:NBN: urn:nbn:hr:178:687033
• Study programme: Title: Veterinary Medicine; Study programme type: university; Study level: integrated undergraduate and graduate; Academic / professional title: doktor/doktorica veterinarske medicine (doktor/doktorica veterinarske medicine)
• Type of resource: Text
• File origin: Born digital
• Access conditions: Open access
• Created on: 2025-01-16 13:52:20