Regeneracija koštanoga tkiva uporabom bioaktivnih molekula i biomaterijala

master's thesis

• Title (english): Regeneration of Bone Tissue Using Bioactive Molecules and Biomaterials
• Author: Nikša Bukvić
• Mentor: Ozren Smolec (mentor)
• Mentor: Marko Pećin (mentor)
• Committee member: Josip Kos (predsjednik povjerenstva)
• Committee member: Petar Džaja (član povjerenstva)
• Committee member: Ozren Smolec (član povjerenstva)
• Granter: University of Zagreb; Faculty of Veterinary Medicine; (Surgery, Orthopaedics and Ophtalmology Clinic); Zagreb
• Defense date and country: 2016-10-06, Croatia
• Scientific / art field, discipline and subdiscipline: BIOMEDICINE AND HEALTHCARE; Veterinary Medicine

Abstract

Napredak u primjeni regenerativnih principa dramatično je utjecao kako na humanu tako i na veterinarsku ortopediju, no ortopedija se javlja kao jedna od najatraktivnijih grana za primjenu regenerativne medicine i tkivnog inženjeringa. Osnovni koncept regenerativne ortopedije temelji se na razumijevanju i preciznom usklađivanju međuodnosa tri osnovne sastavnice: stanica, okoline i nosača. Tkivni inženjering za cilj ima kombiniranje progenitornih ili zrelih matičnih stanica s biokompatibilnim materijalima ili nosačima, sa ili bez odgovarajućih činbenika rasta kako bi se potaknula reparacija i regeneracija. Budući da je razumijevanje molekularnih i staničnih događanja tijekom cjelidbene kaskade postupno povećava, istražuju se nove strategije za poboljšavanje procesa cijeljenja. Razvijen je cijeli niz terapijskih postupaka i bioaktivnih molekula kako bi se poboljšao odgovor organizma i ubrzalo cijeljenje kosti. Neki od primjera su različiti tipovi glukozaminoglikana, faktori rasta, matične stanice, prirodni presadci (auto-, alo- ili ksenograftovi) te nosači s biološkom i sintetskom bazom nastale na temelju tkivnog inženjerstva. Ovi biomaterijali i bioaktivne molekule imaju neka značajna ograničenja, i još uvijek ne postoje općeprihvaćene terapijske metode koje bi zadovoljile sve očekivane zahtjeve u smislu poboljšanja cijeljenja koštanog tkiva. Inženjering koštanog tkiva, kao skup novih terapijskih metoda, mogla bi prevladati mnoga ograničenja uporabe koštanih presadaka.

Abstract (english)

The progress in implementing regenerative principles has affected both the human and the veterinary orthopaedics, with orthopaedics appearing as one of the most attractive areas for application of regenerative medicine and tissue engineering. The basic concept of regenerative orthopaedics is based on the understanding and accurate harmonization of relations between the three major components: cells, environments and carriers. The aim of the tissue engineering is to combine the progenitor or the adult stem cells with biocompatible materials or carriers, with or without the appropriate growth factors, in order to facilitate reparation and regeneration. Since there has been a gradual growth in understanding of the molecular and cellular events during the healing cascade, new strategies to improve the healing process have been explored. The whole row of therapeutic procedures and bioactive molecules have been developed to improve the body response and to accelerate the process of bone healing. Some examples are the different types of glycosaminoglycans, growth factor, stem cells, natural grafts (auto-, allo- and xenografts) as well as scaffolds with biological and synthetic basis developed through tissue engineering. These biomaterials and bioactive molecules have some significant limitations, and there are still no generally accepted therapeutic methods to satisfy all the requirements in terms of improving the healing of the bone tissue. The bone tissue engineering, as a set of new therapeutic methods, has the potential to overcome many of the limitations in terms of the bone graft application.

• Keywords: regeneracija; koštano; tkivo
• Keywords (english): regeneration; bone; tissue
• Language: croatian
• URN:NBN: urn:nbn:hr:178:051400
• Study programme: Title: Veterinary Medicine; Study programme type: university; Study level: integrated undergraduate and graduate; Academic / professional title: doktor/doktorica veterinarske medicine (doktor/doktorica veterinarske medicine)
• Type of resource: Text
• File origin: Born digital
• Access conditions: Open access
• Created on: 2018-07-23 08:01:46