Metabolički sindrom u domaćih životinja

master's thesis

• Title (english): Metabolic Syndrome in Domestic Animals
• Author: Ivan Šimunić
• Mentor: Damir Žubčić (mentor)
• Committee member: Ivana Kiš (predsjednik povjerenstva)
• Committee member: Nada Kučer (član povjerenstva)
• Committee member: Damir Žubčić (član povjerenstva)
• Granter: University of Zagreb; Faculty of Veterinary Medicine; (Internal Diseases Clinic); Zagreb
• Defense date and country: 2016-06-24, Croatia
• Scientific / art field, discipline and subdiscipline: BIOMEDICINE AND HEALTHCARE; Veterinary Medicine

Abstract

Pretilost je čimbenik koji se kako u ljudi, tako i u životinja povezuje s velikim brojem
bolesti što za posljedicu ima skraćen životni vijek. U mesojeda je pretilost uzrok niza
poremećaja, no za razliku od konja i ljudi, kod prvih nisu ustvrđeni sindromi povezanosti sa
adipoznošću. Endokrinološki poremećaji pri metaboličkom sindromu rezultiraju inzulinskom
rezistencijom i dijabetesom tipa 2. Pojedine vrste adipokina masnog tkiva pridonose inzulinskoj
rezistenciji. U konja s metaboličkim sindromom inzulinska rezistencija pogoršana je stanjem
kompenzatorne hiperinzulinemije. Adipoznost goveda okarakterizirana je lipomobilizacijskim
sindromom u kojem izrazita mobilizacija masnog tkiva uzrokuje masno promijenjenu jetru. Uz
sindrom debelog goveda često se nadovezuju ketoza, mastitis, metritis, hipokalcemija,
neaktivni jajnici i ciste jajnika. Ketoza može uzrokovati cirozu jetre, pri čemu životinja gubi
dobra proizvodna svojstva i izlučuje se iz proizvodnje. Uz kvalitetnu ishranu, restriktivnu
prehranu i povećanu tjelesnu aktivnost u liječenju metaboličkog sindroma u životinja
primjenjuje se i medikamentna terapija.

Abstract (english)

Obesity is the factor, both, in humans and in animals, associated with many disease
conditions resulting in a shortened life span. In carnivores, the obesity is the cause of numerous
disorders, but in contrast to humans and horses, it doesn’t provoke the metabolic syndrome in
them. Endocrine disorders in metabolic syndrome result in insulin resistance and type 2
diabetes. Certain types of adipokines from adipose tissue contribute to insulin resistance. In
horses with metabolic syndrome, the insulin resistance is exacerbated by the condition of
compensatory hyperinsulinemia. Cows’ adiposity is characterized by lipomobilisation
syndrome in which exceptional mobilization of adipose tissue leads to fatty liver. To the fat
syndrome in cows, they are often related ketosis, mastitis, metritis, hypocalcemia, inactive
ovaries and ovarian cysts. Ketosis can cause cirrhosis of the liver, for which the animal is losing
its good production properties and is eventually expelled from the production. In the treatment
of metabolic syndrome in animals, it is applied, in addition to quality food, a restrictive diet and
increased physical activity, also the medical therapy.

• Keywords: pretilost; metabolički sindrom; inzulinska rezistencija; adipokini; lipomobilizacijski sindrom
• Keywords (english): obesity; metabolic syndrome; inzuline resistance; adipokines; lipomobilisation syndrome
• Language: croatian
• URN:NBN: urn:nbn:hr:178:595380
• Study programme: Title: Veterinary Medicine; Study programme type: university; Study level: integrated undergraduate and graduate; Academic / professional title: doktor/doktorica veterinarske medicine (doktor/doktorica veterinarske medicine)
• Type of resource: Text
• File origin: Born digital
• Access conditions: Open access
• Created on: 2018-07-23 10:50:42