Pregled podudarnosti citopatoloških i histopatoloških dijagnoza od istovjetnih lezija sa Zavoda za veterinarsku patologiju od 2009. do 2016. godine

master's thesis

• Title (english): Review of the Congruence between Cytopathological and Histopathological Diagnoses of Archive Cases 2009-2016 from Department of Veterinary Pathology Zagreb
• Author: Maja Dvoršćak
• Mentor: Ivan-Conrado Šoštarić-Zuckermann (mentor)
• Mentor: Marko Hohšteter (mentor)
• Committee member: Andrea Gudan Kurilj (predsjednik povjerenstva)
• Committee member: Marko Hohšteter (član povjerenstva)
• Committee member: Ivan-Conrado Šoštarić-Zuckermann (član povjerenstva)
• Granter: University of Zagreb; Faculty of Veterinary Medicine; (Department of Veterinary Pathology); Zagreb
• Defense date and country: 2018-07-12, Croatia
• Scientific / art field, discipline and subdiscipline: BIOMEDICINE AND HEALTHCARE; Veterinary Medicine

Abstract

Citološka pretraga se rutinski primjenjuje u kliničkom radu radi svoje učinkovitosti, brzine i jednostavnosti. Patohistološka pretraga je složenija, zahtijeva više vremena za pripremu preparata, ali je ona zlatni standard za analiziranje arhitekture tkiva. Obje metode se provode na Zavodu za veterinarsku patologiju, no do sada nije ispitivana razina njihove podudarnosti za istovjetne lezije. Pretragom arhive Zavoda za veterinarsku patologiju, pronađeni su svi slučajevi (parovi) citoloških i histoloških pretraga od istovjetnih lezija u razdoblju od 2009. – 2016. godine. Obavljena je statistička analiza ispravnosti i korisnosti citoloških slučajeva u odnosu na histološke. Ne uključujući nedostatne slučajeve (20,7%), 80,4% slučajeva pokazuje potpunu ili djelomičnu podudarnost, a 19,6% nepodudarnost. Većina uzoraka je bila upravo iz područja kože (50,6%), te je u tom području 20,5% dijagnoza činio mastocitom, dok su ostale dijagnoze činile 79,5%. Rezultati su pokazali 96,6% podudarnosti za mastocitom, neovisno o sustavu. Ovakvi rezultati su podjednaki onim dobivenima u sličnim istraživanjima, bilo u humanoj ili veterinarskoj medicini. Predmetno istraživanje je pokazalo visoku razinu podudarnosti između citopatoloških i histopatoloških dijagnoza te je dokazalo da je citopatološka pretraga, koja se nadopunjuje s histopatološkom pretragom, vrlo važna i korisna inicijalna i orijentacijska pretraga u klasificiranju kožnih lezija domaćih životinja.

Abstract (english)

Cytological examination is routinely applied in clinical work because of its efficiency, speed and simplicity. Histological examination is more complex, it requires more time for specimen preparation, but it is the gold standard for analyzing tissue architecture. Both methods are performed by the Department of Veterinary Pathology Veterinary Faculty, University of Zagreb, but the rate of congruency between those methods has not yet been investigated. The Department archives were searched for all cases (pairs) that went through both cytological and histological examination of the same lesion, between 2009 and 2016. Altogether 251 cases were found and the majority were canine. Statistical analysis of accuracy and efficiency of cytological cases in relation to histological cases was conducted on 251 cases registered in the Department archives between January the 1st 2009 and January the 1st 2016. With indecisive (non-diagnostic) cases excluded (20,7%), the rate of complete or partial congruency between cytological and histological diagnosis was 80,4%, and the rate of non-congruency was 19,6%. Majority of samples were taken from the skin region (50,6%), where mastocytoma had the rate of 20,5%, as opposed to other lesions which combined had a rate of 79,5%. Results have shown 96,6% congruency in mastocytoma cases, regardless of the region. The results are similar to those obtained in comparable researches, either human or veterinary medicine. Research concerned has shown a great congruency rate between cytological and histological diagnosis and cytological examination was proven (complemented with histological examination) as very important and useful screening method in classification of skin lesions in domestic animals.

• Keywords: citološka pretraga; histološka pretraga; analiza podudarnosti; koža; mastocitom
• Keywords (english): cytological examination; histological examination; compatibility analysis; skin; mastocytoma
• Language: croatian
• URN:NBN: urn:nbn:hr:178:744096
• Study programme: Title: Veterinary Medicine; Study programme type: university; Study level: integrated undergraduate and graduate; Academic / professional title: doktor/doktorica veterinarske medicine (doktor/doktorica veterinarske medicine)
• Type of resource: Text
• File origin: Born digital
• Access conditions: Open access
• Created on: 2018-07-24 07:07:44