Fibroadenomatozna hiperplazija mliječne žlijezde mačaka

master's thesis

• Title (english): Feline Mammary Fibroadenomatous Hyperplasia - FAH
• Author: Nina Dvojković
• Mentor: Marko Samardžija (mentor)
• Mentor: Nino Maćešić (mentor)
• Committee member: Goran Bačić
• Committee member: Nino Maćešić
• Committee member: Marko Samardžija
• Granter: University of Zagreb; Faculty of Veterinary Medicine; (Reproduction and Obstetrics Clinic); Zagreb
• Defense date and country: 2014-10-07, Croatia
• Scientific / art field, discipline and subdiscipline: BIOMEDICINE AND HEALTHCARE; Veterinary Medicine; Veterinary Clinical Sciences

Abstract

FAH (fibroadenomatozna hiperplazija mliječne žlijezde mačke) predstavlja benignu proliferaciju jedne ili više mliječne žlijezde koje se mogu pojaviti u ženskih i muških mačaka. Javlja se kod intaktnih mačaka bilo koje dobi, u gravidnih mačaka te mužjaka i ženki pod progesteronskim liječenjem. Razvoj i rast mliječne žlijezde je pod kontrolom progesterona, čiji su učinci uglavnom posredovani progesteron receptorom (PR) na stromalnim i epitelnim stanicama. Makroskopski, FAH lezije se pojavljuju kao čvrste, ograničene, ali nekapsulirane mase, koje se mogu podijeliti na dva makroskopska tipa: solidan tip, glatke površine tkiva s oskudnom razinom tekućine; i parenhimski, intraduktalni tip, s prostorom ispunjenim tekućinom. U nekim teškim situacijama ili dugotrajno, FAH može koegzistirati s mastitisom ili ulceracijom. Glavni klinički znak je natečeno, tvrdo tkivo mliječne žlijezde. Biopsija je često najprihvatljiviji postupak koji se koristi za potvrdu dijagnoze FAH-a. Za većinu FAH-a može biti potrebno 21 do 24 dana da se u potpunosti ukloni proširenje mliječne žlijezde, ali to može varirati ovisno o odabranom terapijskom pristupu. Ovarijektomija i ovariohisterektomija smatraju se prikladnim za liječenje FAH-a, jer se time naglo snižava razina progesterona.

Abstract (english)

Feline mammary fibroepithelial hyperplasia represents a benign proliferation of one or more mammary glands that may occur in both the female and male cat. Disease occurs in intact queens of any age, in pregnant females and in female or male cats under progestin treatment. Development and growth of the mammary gland is under the control of progesterone, which effects are mainly mediated through the progesterone receptor (PR) on stromal and epithelial cells. Macroscopically, FEH lesions appear as firm, well-circumscribed but unencapsulated masses, that may present two types of macroscopic patterns: the solid type, of smooth-surfaced tissue with scant fluid; and the parenchymal, intraductal pattern, with fluid-filled spaces. The major clinical sign is the swollen, firm mammary gland tissue. In some severe or prolonged situations, the primary FEH may co-exist with mastitis or ulceration. Biopsies are often referred as being the most acceptable form to confirm the diagnosis of mammary fibroepithelial hyperplasia. For most FEH situations 21-24 days may be needed to fully reversion of the mammary gland enlargement, but it may vary with the selected therapeutic approach. Ovariectomy and ovariohysterectomy considered suitable for the treatment of FAH because it suddenly lower progesterone levels

• Keywords: biopsija; FAH; mastitis; mliječna žlijezda; ovariohisterektomija; progesteron.
• Keywords (english): biopsy; FAH; mastitis; mammary gland; ovariohisterectomy; progesteron
• Language: croatian
• URN:NBN: urn:nbn:hr:178:405785
• Study programme: Title: Veterinary Medicine; Study programme type: university; Study level: integrated undergraduate and graduate; Academic / professional title: doktor/doktorica veterinarske medicine (doktor/doktorica veterinarske medicine)
• Type of resource: Text
• File origin: Born digital
• Access conditions: Access restricted to students and staff of home institution
• Created on: 2016-01-12 09:19:00