Zarazni peritonitis mačaka

master's thesis

• Title (english): Feline Infectious Peritonitis
• Author: Denis Eles
• Mentor: Zrinka Štritof (mentor)
• Mentor: Matko Perharić (komentor)
• Committee member: Suzana Hađina (predsjednik povjerenstva)
• Committee member: Zrinka Štritof (član povjerenstva)
• Committee member: Matko Perharić (član povjerenstva)
• Granter: University of Zagreb; Faculty of Veterinary Medicine; (Department of Microbiology and Infectious Diseases with Clinic); Zagreb
• Defense date and country: 2020-06-16, Croatia
• Scientific / art field, discipline and subdiscipline: BIOMEDICINE AND HEALTHCARE; Veterinary Medicine; Veterinary Clinical Sciences

Abstract

Zarazni peritonitis mačaka je virusna zarazna bolest uzrokovana mutiranim sojem mačjeg koronavirusa. Bolest se obično razvija u mačaka u uzgajivačnicama, skloništima, privremenim utočištima i gušće naseljenim slobodnim skupinama mačaka. Učestalost je značajno veća među mačićima i mladim mačkama. Smrtnost je vrlo visoka jednom kad dođe do pojave kliničkih znakova bolesti. Virulencija i infekcijska doza ovisiti će o tipu i soju virusa. Izvore infekcije predstavljaju bolesne i zaražene životinje, doživotni kliconoše i kontaminirani predmeti. Virus se najčešće širi neizravnim dodirom. Izmet sadrži FCoV u visokim koncentracijama, pa je tako fekalno-oralni prijenos najčešći. K linička slika bolesti može se pojaviti tijekom 2-3 tjedna nakon infekcije do nekoliko mjeseci, a katkad čak i nekoliko godina, ovisno o imunosnom statusu životinje. Pregledom životinje razlikujemo dva klinička oblika bolesti: mokri i suhi. Kod mokrog oblika dolazi do nakupljanja tekućine u tjelesnim šupljinama, a kod suhog do stvaranja granuloma po parenhimskim organima i crijevima. Patoanatomske i histološke promijene pokazuju da je najčešće riječ o kombinaciji mokrog i suhog oblika bolesti. Postavljanje konačne dijagnoze moguće je tek post mortem patohistološkim nalazom koji se smatra zlatnim standardom u dijagnostici ove bolesti. Nema dokazano učinkovitog etiološkog liječenja, već je ono isključivo simptomatsko. Mjere opće profilakse teško je učinkovito provesti, a imunoprofilaksa se ne provodi.

Abstract (english)

Feline infectious peritonitis is a viral disease caused by a mutated strain of feline coronavirus. The disease usually develops in cats in kennels, shelters, temporary shelters and more densely populated free groups of cats. The frequency is significantly higher among kittens and young cats. Mortality is extremely high once clinical signs appear. The virulence and infectious dose depend on the virus type and strain. Sick and infected animals, persistent carriers, contaminated litter trays, bowls and combs may be the source of infection. The virus is transmitted by indirect contact. Faeces contain FCoV at high concentrations, and the faecooral route of transmission is most important. The incubation period is from 2 to 3 weeks up to a few months, and sometimes years, depending on the immunological status of the animal. Two different forms of disease have been distinguished: effusive (wet form) and non-effusive (dry form). The wet form is characterized by the accumulation of fluid in the body cavities, and the dry form with granulomatous infiltration of the parenchymal organs and intestines. Pathoanatomical and histological changes show that it is most often a combination of wet and dry forms of the disease. A reliable diagnosis is possible only by post mortem pathohistological finding, which is considered the gold standard in the diagnosis of this disease. Treatment of feline infectious peritonitis involves only symptomatic therapy of the disease, as opposed to treating the cause. Feline coronavirus is widespread in a multi-cat environment and it is difficult to minimize the risk of spread of the infection. Vaccination is not routinely used in practice.

• Keywords: zarazni peritonitis mačaka; mačji koronavirus; klinička slika; dijagnoza; liječenje
• Keywords (english): feline infectious peritonitis; feline coronavirus; clinical manifestation; diagnosis; treatment
• Language: croatian
• URN:NBN: urn:nbn:hr:178:902597
• Study programme: Title: Veterinary Medicine; Study programme type: university; Study level: integrated undergraduate and graduate; Academic / professional title: doktor/doktorica veterinarske medicine (doktor/doktorica veterinarske medicine)
• Type of resource: Text
• File origin: Born digital
• Access conditions: Open access
• Created on: 2020-12-04 09:04:12