AMANTADIN I GABAPENTIN U LIJEČENJU OSTEOARTRITISA U PASA

master's thesis

• Title (english): AMANTADINE AND GABAPENTIN IN THE TREATMENT OF OSTEOARTHRITIS IN DOGS
• Author: Iva Milaković
• Mentor: Mario Kreszinger (mentor)
• Committee member: Marko Pećin (predsjednik povjerenstva)
• Committee member: Tugomir Karadjole (član povjerenstva)
• Committee member: Mario Kreszinger (član povjerenstva)
• Committee member: Andrija Musulin (član povjerenstva)
• Granter: University of Zagreb; Faculty of Veterinary Medicine; Zagreb
• Defense date and country: 2021-10, Croatia
• Scientific / art field, discipline and subdiscipline: BIOMEDICINE AND HEALTHCARE; Veterinary Medicine; Veterinary Clinical Sciences

Abstract

Osteoartritis (OA) je kronično, progresivno, degenerativno upalno patološko stanje
zglobova obilježeno degeneracijom zglobne hrskavice i stvaranjem osteofita. U veterinarskoj
praksi vrlo je zahtjevno i važno prepoznati kronično prisutnu neuropatsku bol u pacijenata s
OA. Prvi lijek izbora kod većina pacijenata sa OA su nesteroidni protuupalni lijekovi (NSPUL).
NSPUL ne pružaju potpuno ili dostatno ublažavanje boli kod OA, imaju značajan negativan
učinak na hrskavični matriks te inhibiraju reparativne mehanizme zgloba. Zbog toga se liječenju
OA pristupa multimodalnim pristupom, odnosno kombinacijom više lijekova s različitim
načinima djelovanja. Amantadin neutralizira središnje senzibilizacije inhibicijom NMDA
receptora, a gabapentin ometa i mijenja način prijenosa boli u leđnoj moždini. Oba lijeka
pokazuju sinergijski učinak s NSPUL lijekovima.
Amantadin i gabapentin trebali bi postati sastavni dio protokola multimodalnog pristupa
liječenju OA u pasa.

Abstract (english)

Osteoarthritis (OA) is a chronic, progressive, degenerative inflammatory pathological
condition of the joints characterized by degeneration of the articular cartilage and the
formation of osteophytes. In veterinary practice, it is very demanding and important to
recognize chronically present neuropathic pain in patients with OA. The first drug of choice in
most patients is nonsteroidal anti-inflammatory drugs (NSAID). However, NSAIDs do not
provide complete or sufficient pain relief in OA, have a significant negative effect on the
cartilage matrix and inhibit the reparative mechanisms of the joint. Therefore, the treatment of
OA is approached by a multimodal approach, that is a combination of several drugs with
different modes of action. Amantadine neutralizes central sensitization by inhibiting NMDA
receptors, and Gabapentin interferes and changes the way spinal cord pain is transmitted.
Both drugs show a synergistic effect with NSAID drugs.
Amantadine and Gabapentin should become an integral part of a protocol for a
multimodal approach for the treatment of OA in dogs.

• Keywords: Amantadin; gabapentin; kronična bol; NSPUL
• Keywords (english): Amantadine; chronic pain; Gabapentin; NSAID; osteoarthritis
• Language: croatian
• URN:NBN: urn:nbn:hr:178:318623
• Study programme: Title: Veterinary Medicine; Study programme type: university; Study level: integrated undergraduate and graduate; Academic / professional title: doktor/doktorica veterinarske medicine (doktor/doktorica veterinarske medicine)
• Type of resource: Text
• File origin: Born digital
• Access conditions: Open access
• Created on: 2021-10-27 08:08:24