KOMPARATIVNA ANALIZA LIMFOMA PASA DIJAGNOSTICIRANIH NA ZAVODU ZA VETERINARSKU PATOLOGIJU VETERINARSKOG FAKULTETA SVEUČILIŠTA U ZAGREBU

master's thesis

• Title (english): COMPARATIVE ANALYSIS OF CANINE LYMPHOMAS DIAGNOSED AT THE DEPARTMENT OF VETERINARY PATHOLOGY OF THE VETERINARY FACULTY OF THE UNIVERSITY OF ZAGREB
• Author: Mavro Matasović
• Mentor: Marko Hohšteter (mentor)
• Mentor: Lidija Medven Zagradišnik (mentor)
• Committee member: Andrea Gudan Kurilj (predsjednik povjerenstva)
• Committee member: Lidija Medven Zagradišnik (član povjerenstva)
• Committee member: Marko Hohšteter (član povjerenstva)
• Committee member: Doroteja Huber (član povjerenstva)
• Granter: University of Zagreb; Faculty of Veterinary Medicine; Zagreb
• Defense date and country: 2023-05-08, Croatia
• Scientific / art field, discipline and subdiscipline: BIOMEDICINE AND HEALTHCARE; Veterinary Medicine; Veterinary Clinical Sciences

Abstract

Limfomi u pasa predstavljaju skupinu neoplastičnih bolesti koje nastaju klonalnom ekspanzijom stanica limfoidne linije u centralnim ili perifernim limfnim tkivima te se potom mogu širiti u ostala tkiva. Limfomi su najčešći tumori hematopoetskog sustava u pasa te kao takvi imaju veliki klinički značaj u veterinarskoj medicini. Dijagnostika limfoma u pasa provodi se na temelju različitih pretraga poput citološke, histopatološke, imunocitokemijske i imunohistokemijske pretrage te uporabom molekularnih metoda dijagnostike. Usprkos sve većeg fokusa znanstvene zajednice na ovo područje, epidemiologija limfoma u pasa još je nedovoljno istražena, posebice u Republici Hrvatskoj, zbog različitih izazova s kojima se epidemiolozi susreću u svojem znanstvenom radu u veterinarskoj medicini. U ovom istraživanju provedena je analiza dostupnih podataka o dijagnozama limfoma u pasa postavljenim na Zavodu za veterinarsku patologiju Veterinarskog fakulteta Sveučilišta u Zagrebu između 2009. i 2021. godine. Raspodjela pasa s limfomima s obzirom na dob, spol i čistokrvnost pasmine u skladu je s postojećom literaturom. Usporedbom brojnosti pasa određenih pasmina s limfomom i brojnosti pasa odgovarajućih pasmina u Issa Vams Tec sustavu procijenjena je predispozicija određenih pasmina za razvitak limfoma. Visoku predispoziciju prema tim podatcima pokazali su bulmastif, shar pei i samojed, a malu su pokazali jorkširski terijer, zapadnoškotski bijeli terijer i maltezer. Cjelovitih dijagnoza psećih limfoma, prema trenutno preporučenim sustavima klasifikacije, postavljenih na Zavodu za veterinarsku patologiju bilo je malo, vjerojatno zbog nevoljkosti vlasnika da plate pretrage. Zbog toga, u daljnjim istraživanjima epidemiologije psećih limfoma na području Republike Hrvatske autor preporučuje pretragu uzoraka arhiviranih na Zavodu za veterinarsku patologiju.

Abstract (english)

Lymphomas in dogs represent a group of neoplastic diseases that arise from the clonal expansion of cells of the lymphoid lineage in central or peripheral lymphatic tissues and can then spread to other tissues. Lymphomas are the most common tumors of hematopoietic system in dogs and as such they have great clinical significance in veterinary medicine. Diagnosis of lymphoma in dogs is carried out on the basis of various examinations such as cytological, histopathological, immunocytochemical and immunohistochemical examinations, and the use of molecular diagnostic methods. Despite the increasing focus of the scientific community on this area, the epidemiology of lymphoma in dogs is still insufficiently researched, especially in the Republic of Croatia, due to the various challenges that epidemiologists face in their scientific work in veterinary medicine. In this research, an analysis of available data on lymphoma diagnoses in dogs made at the Department of Veterinary Pathology of the Veterinary Faculty of the University of Zagreb between 2009 and 2021 was carried out. The distribution of dogs with lymphomas with regard to age, sex and breed purity is in accordance with the existing literature. By comparing the number of dogs of certain breeds with lymphoma and the number of dogs of the corresponding breeds in the Issa Vams Tec system, the predisposition of certain breeds to the development of lymphoma was assessed. Bullmastiff, Shar Pei and Samoyed showed a high predisposition according to these data, while Yorkshire terrier, West Scottish white terrier and Maltese showed a low predisposition. Complete diagnoses of lymphoma in dogs, according to the currently recommended classification systems, made at the Department of Veterinary Pathology were few, probably due to the owners' reluctance to pay for tests. For this reason, in further research on the epidemiology of canine lymphoma in the Republic of Croatia, the author recommends performing examination of the samples archived at the Department of Veterinary Pathology.

• Keywords: limfom; pas; Republika Hrvatska; epidemiologija
• Keywords (english): lymphoma; dog; Republic of Croatia; epidemiology
• Language: croatian
• URN:NBN: urn:nbn:hr:178:462727
• Study programme: Title: Veterinary Medicine; Study programme type: university; Study level: integrated undergraduate and graduate; Academic / professional title: doktor/doktorica veterinarske medicine (doktor/doktorica veterinarske medicine)
• Type of resource: Text
• File origin: Born digital
• Access conditions: Open access
• Created on: 2023-05-22 11:24:00