Patogeneza upalne bolesti crijeva u pasa i mačaka i sličnosti s Crohnovom bolesti i ulceroznim kolitisom u ljudi

master's thesis

• Title (english): Pathogenesis of inflammatory bowel disease in dogs and cats and similarities with Crohn's disease and ulcerative colitis in humas
• Author: Marta Pandžić
• Mentor: Maja Belić (mentor)
• Mentor: Mirna Robić (mentor)
• Committee member: Romana Turk (predsjednik povjerenstva)
• Committee member: Mirna Robić (član povjerenstva)
• Committee member: Maja Belić (član povjerenstva)
• Committee member: Nina Poljičak Milas (član povjerenstva)
• Granter: University of Zagreb; Faculty of Veterinary Medicine; Zagreb
• Defense date and country: 2023-10, Croatia
• Scientific / art field, discipline and subdiscipline: BIOMEDICINE AND HEALTHCARE; Veterinary Medicine; Basic and Preclinical Veterinary Sciences

Abstract

Upalna bolest crijeva u ljudi i životinja kronična je bolest nepoznatog uzroka koja se sve češće
javlja. Kod ljudi su poznate Crohnova bolest i ulcerozni kolitis, koje se prvenstveno razlikuju po
dijelu probavnog sustava koji je zahvaćen upalom. U pasa i mačaka upalna bolest crijeva naziva
se prema upalnom infiltratu nađenom u sluznici crijeva.
Upalna bolest crijeva ljudi i životinja pokazuju određene sličnosti i razlike, a glavna poveznica im
je da patogeneza, kao ni uzrok bolesti, nije do kraja poznata. Među najvažnijim problemima ističu
se disbioza, mutacije gena na Toll-like i NOD 2 receptorima, defekti antigen prezentirajućih
stanica, ovisno o vrsti i bolesti prevladavajuće Th 1 ili Th 2 populacije stanica te produkcija
proupalnih medijatora. Sve ove nepravilnosti zajedno doprinose nastajanju i kontinuiranom
pokretanju upale iznova. Neki vanjski faktori, kao na primjer genetika, disbioza, gubitak
tolerancije na komenzale, prehrana i pasmina, znatnije istraženi u ljudi, prepoznati su kao rizik od
oboljenja. Zbog sve većeg broja pacijenata s upalnom bolesti crijeva, javlja se potreba za
istraživanjem i razjašnjavanjem nepoznanica ove bolesti u veterinarskoj medicini.
Upalna bolest crijeva manifestira se kroničnim gastrointestinalnim simptomima s epizodama
egzacerbacije i remisije s mogućim ekstraintestinalnim komplikacijama u ljudi. Dijagnostika
bolesti je problematična te nema standardizirane metode. Ovisno o stupnju bolesti u ljudi, od
lijekova se upotrebljavaju kortikosteroidi ili imunomodulatori, inhibitori TNF te antagonisti
integrinskih receptora. Psi i mačke većinom pokazuju dobre reakcije na kortikosteroide,
imunomodulatore, antibiotike te pravilnu hranidbu.

Abstract (english)

Inflammatory bowel disease in humans and animals is a chronic condition of unknown origin that
is becoming increasingly common. In humans, it is known as Crohn’s disease and ulcerative colitis,
which primarily differ in the part of the digestive system affected by inflammation. In dogs and
cats, inflammatory bowel diseases are named based on the inflammatory infiltrate found in the
intestinal mucosa.
Inflammatory bowel diseases in humas and animals exhibit certain similarities differences, with
the main connection being that the pathogenesis, as well as the cause of the disease, is not fully
understood. Among the most important issues, dysbiosis, gene mutations in Toll-like and NOD2
receptors, defects in antigen-presenting cells, depending on the type and prevailing disease, Th1
or Th2 cell populations, and the production of pro-inflammatory mediators, are highlighted. All of
these irregularities contribute to the onset and continuous reactivation of inflammation. Some
external factors, more extensively studied in humas, have been identified as risk factors for the
disease. Due to the increasing number of patients with inflammatory bowel disease, there is a need
for research and clarification of the unknowns of this disease in veterinary medicine.
Inflammatory bowel disease manifests as chronic gastrointestinal symptoms with episodes of
exacerbation and remission with possible extraintestinal complications in humas. Diagnosis of the
disease is problematic and there is no standardized method. Depending on the severity of the
disease in humans, medications such as corticosteroids, immunomodulators, TNF inhibitors and
integrin receptor antagonists are used. Dogs and cats mostly respond well to corticosteroids,
immunomodulators, antibiotics and proper nutrition.

• Keywords: upalna bolest crijeva; psi; mačke; Crohnova bolest; ulcerozni kolitis
• Keywords (english): inflammatory bowel disease; dogs; cats; Crohn's disease; ulcerative colitis
• Language: croatian
• URN:NBN: urn:nbn:hr:178:223729
• Study programme: Title: Veterinary Medicine; Study programme type: university; Study level: integrated undergraduate and graduate; Academic / professional title: doktor/doktorica veterinarske medicine (doktor/doktorica veterinarske medicine)
• Type of resource: Text
• File origin: Born digital
• Access conditions: Open access
• Created on: 2023-10-17 09:43:20