Title Intrakranijalni tumori pasa Title (english) Canine intracranial tumours Author Anamarija Nevistić Mentor Ivana Kiš (mentor)Mentor Mirna Brkljačić (mentor)Committee member Gabrijela Jurkić Krsteska (predsjednik povjerenstva) Committee member Ivana Kiš (član povjerenstva)Committee member Mirna Brkljačić (član povjerenstva)Committee member Nada Kučer (član povjerenstva)Granter University of Zagreb Defense date and country 2024-09, Croatia Scientific / art field, BIOMEDICINE AND HEALTHCARE Abstract Intrakranijalne neoplazije su čest uzrok neuroloških znakova u pasa, a najviše slučajeva
opisano je u pasa starijih od 5 godina. Prevalencija iznosi oko 3-4,5%, s otprilike podjednakom
pojavnošću primarnih i sekundarnih neoplazija.
Meningeomi su najčešći primarni tumori mozga u pasa, a uz gliome i neoplazije
koroidnog pleksusa čine 90% svih primarnih tumora mozga. Najčešće obolijevaju velike
pasmine pasa, a utvrđena je predispozicija za nastanak pojedinih tumora kod brahicefaličnih i
dolihocefaličnih pasmina. Najčešći sekundarni tumori mozga su hemangiosarkomi, tumori
hipofize, limfomi i metastaski karcinomi.
Pojava progresivnih neuroloških znakova u pasa srednje i starije dobi indikativna je za
postojanje intrakranijalne neoplazije. Osnova ante mortem dijagnostike je MR/CT, ali zbog
sličnosti s ne-neoplastičnim lezijama, patohistološka pretraga je jedini način postavljanja
definitivne dijagnoze. Liječenje može biti palijativno, specifično ili njihova kombinacija.
Pregledom arhivskih podataka „Vef protokola“ Veterinarskog fakulteta Sveučilišta u
Zagrebu, tijekom petogodišnjeg razdoblja utvrđeno je 15 pasa koji su zadovoljili uključne
kriterije postojanja suspektnog intrakranijalnog tumora na nalazu CT-a/MR-a i potpisanog
pristanka vlasnika pasa za korištenje podataka.
Od ukupno 15 intrakranijalnih tumora, 11 je bilo primarnih i 4 sekundarna. Najčešći
primarni tumori pripadali su skupini neuroepitelnih neoplazija (8/15), dok su tumori hipofize
bili najčešći sekundarni tumori (3/15). Općenito, 11/15 pasa pripadali su skupini manjih
pasmina pasa (<15 kg), a najzastupljenije su bile brahicefalične pasmine (7/15).
Medijan dobi kod pojave kliničkih znakova iznosio je 8 godina (2-16 godina), a najčešći
klinički znak bili su napadaji. Najveći broj pasa liječen je palijativno. Klinička slika je kod svih
pasa bila progresivna, a najčešći ishod bolesti bila je eutanazija (6/9).
S obzirom na mali uzorak, nedostatak definitivne dijagnoze kod svih pasa uključenih u
istraživanje i retrospektivne prirode istraživanja, potrebno je provesti daljnja prospektivna istraživanja u svrhu dobivanja objektivnih zaključaka o pojavnosti intrakranijalnih neoplazija
u pasa u Hrvatskoj.
Abstract (english) Intracranial neoplasia is a common cause of neurological symptoms in dogs, with most
cases described in dogs older than 5 years. The prevalence is approximately 3-4.5%, with
almost equal occurrence of primary and secondary neoplasia.
Meningiomas are the most common primary brain tumours in dogs, and along with
gliomas and choroid plexus tumours account for 90% of all primary brain tumours. Largebreed dogs are most often affected, and breed predisposition has been established in
brachycephalic and dolichocephalic breeds for certain tumour types. The most common
secondary brain tumours are hemangiosarcoma, pituitary tumours, lymphoma and metastatic
carcinoma.
Progressive neurological signs in middle-aged and older age are indicative of
intracranial neoplasia. The basis of antemortem diagnosis is MRI/CT, but due to the
similarities with non-neoplastic lesions, the pathohistological examination is the only way to
establish a definitive diagnosis. Treatment can be symptomatic, specific, or a combination
thereof.
After reviewing the „Vef protocol“ database of the Faculty of Veterinary Medicine of
the University of Zagreb, 15 dogs were identified over a five-year period that met the inclusion
criteria of the presence of a suspected intracranial tumour on CT/MRI findings, along with the
owner's signed consent for the use of data.
Out of 15 intracranial tumours, 11 were primary and 4 were secondary. The most
common primary tumours were neuroepithelial neoplasia (8/15), while pituitary tumours were
the most common secondary tumours (3/15). In general, 11/15 dogs were small-breed dogs
(<15 kg), and brachycephalic breeds were overrepresented (7/15).
The median age at the onset of clinical signs was 8 years (2-16 years), and the most
common clinical sign was seizures. The largest number of dogs were treated palliatively. The
clinical signs in all dogs were progressive, and the most common outcome of the disease was
euthanasia (6/9).Due to the small sample, the lack of a definitive diagnosis in all dogs included in the
study and the retrospective nature, it is necessary to conduct further prospective studies to
obtain objective conclusions about the incidence of intracranial neoplasia in dogs in Croatia.
Keywords
pas
gliom
meningeom
intrakranijalno
tumor
Keywords (english)
dog
glioma
meningioma
intracranial
tumour
Language croatian URN:NBN urn:nbn:hr:178:726497 Study programme Title: Veterinary Medicine Type of resource Text File origin Born digital Access conditions Open access Terms of use Created on 2024-10-30 09:15:32
