Poremećaji funkcije štitne žlijezde u pasa i mačaka

master's thesis

• Title (english): Disorders of Thyroid Function in Dogs and Cats
• Author: Barbara Vračar
• Mentor: Maja Belić (mentor)
• Mentor: Romana Turk (mentor)
• Committee member: Mirna Robić (predsjednik povjerenstva)
• Committee member: Maja Belić (član povjerenstva)
• Committee member: Romana Turk (član povjerenstva)
• Granter: University of Zagreb; Faculty of Veterinary Medicine; (Department of Pathophysiology); Zagreb
• Defense date and country: 2016-09-28, Croatia
• Scientific / art field, discipline and subdiscipline: BIOMEDICINE AND HEALTHCARE; Veterinary Medicine; Veterinary Clinical Sciences

Abstract

Među bolestima štitnjače koje se javljaju u pasa i mačaka nesumnjivu važnost imaju hipotireoidizam i hipertireoidizam. Kada govorimo o hipotireozi, govorimo o najčešćem endokrinološkom poremećaju u pasa u kojem dolazi do prekomjernog stvaranja hormona štitnjače. Sama terapija pasa usmjerena je dakle na medikamentozno liječenje tj. na nadoknadu hormona štitnjače.
Iako je T3 metabolički aktivni oblik hormona štitnjače, nije izbor terapije. Primarna prednost pružanja prohormona T4 je taj da tijelo ima priliku regulirati količinu T3 generirana normalnim fiziološkim mehanizmima. Odgovarajuća T4 terapija rezultira u normalnim koncentracijama T4 i T3. Najprimjenjiviji oblik terapije je oralna terapija sintetskog l-tiroksina u početnoj dozi od 10 μ/kg dva puta dnevno. Kontrolni pregled bi se trebao obaviti za dva mjeseca.
Hipotireoidizam je jedna od najzahvalnijih bolesti za liječenje zbog lakoće lijećenja i njenog pozitivnog odgovora na lijećenje. Sa odgovarajućom terapijom i redovitim kontrolnim pregledima svakih pola godine, obično sve promjene povezane sa hipotireoidizmom postanu reverzibilne. Dugoročna prognoza za ovu bolest je odlična.
Postoje tri opcije za eliminiranje pretjerane produkcije tiroksina u hipertireotičnih mačaka, a to su kirurška tireodektomija, terapija radioaktivnim jodom te inhibicija sekrecije hormona lijekovima.
Za mačke sa hipertireozom koje nisu razvile teške komplikacije poput srčanih i bubrežnih bolesti prognoza za očuvanja zdravlja je odlična nakon uspješne kirurške intervencije. Nakon terapije radioaktivnim jodom prognoza je jednako dobra ili čak i bolja. U većini hipertireotičnih mačaka metamizol ili karbamizol dovode do poboljšanja.

Abstract (english)

Among thyroid diseases that occur in dogs and cats undoubtedly great importance carry hypothyroidism and hyperthyroidism. Hypothyroidism is the most common endocrine disorder in dogs which is marked by excessive secretion of thyroid hormones. The therapy for dogs is therefore focused on drug therapy ie. the compensation of thyroid hormones.
Although T3 is the metabolically active thyroid hormone, it is not the supplement of choice. A primary advantage of providing the “prohormone” T4 is that the body is given the oppourtunity to regulate the amount of T3 generated by normal physiologic mechanisms. Appropriate T4 therapy results in normal levels of both T4 and T3. Most commonly oral supplementation with tablets of synthetic l-thyroxine is started at a dose rate of 10 ng/kg twice daily. A follow-up examination is made after two months.
Hypothyroidism is one of the most gratifying diseases to treat because of the ease and completeness with which it responds to treatment. With appropriate treatment and follow-up examinations every half year, usually all of the alterations associated with hypothyroidism are reversible. The long term prognosis is excellent.
There are three options for eliminating the excess production of T4: surgical thyroidectomy, radioiodine ablation of the thyroid and inhibition of secretion by antithyroid drugs. In cats without severe complicating cardiac or kidney disease the prognosis for restoration of health is excellent after successful surgey. After raioiodine treatment the prognosis is as good or even better. In the great majority of hyperthyroid cats either methimazole or carbimazole is effective.

• Keywords: štitnjača; žlijezde; poremećaji
• Keywords (english): Thyroid; glands; disfunction
• Language: croatian
• URN:NBN: urn:nbn:hr:178:633707
• Study programme: Title: Veterinary Medicine; Study programme type: university; Study level: integrated undergraduate and graduate; Academic / professional title: doktor/doktorica veterinarske medicine (doktor/doktorica veterinarske medicine)
• Type of resource: Text
• File origin: Born digital
• Access conditions: Open access
• Created on: 2018-07-23 07:42:10