Procjena pokazatelja sindroma sustavnog upalnog odgovora u pasa

master's thesis

• Title (english): Assessement of Parameters Within Systemic Inflammatory Response Syndrome in Dogs
• Author: Petra Dmitrović
• Mentor: Dražen Vnuk (mentor)
• Committee member: Tomislav Babić
• Committee member: Andrija Musulin
• Committee member: Dražen Vnuk
• Granter: University of Zagreb; Faculty of Veterinary Medicine; (Surgery, Orthopaedics and Ophtalmology Clinic); Zagreb
• Defense date and country: 2015-10-16, Croatia
• Scientific / art field, discipline and subdiscipline: BIOMEDICINE AND HEALTHCARE; Veterinary Medicine; Veterinary Clinical Sciences

Abstract

Sindrom sustavnog upalnog odgovora (SSUO) je klinicka manifestacija sistemski proširene
upale, razlicitog uzroka. Neki od najcešcih uzroka su sepsa, trauma, opekline i novotvorine.
Ovaj sindrom cesto se povezuje s povecanim morbiditetom i mortalitetom u životinja. U ovo
istraživanje ukljuceno je deset pasa zaprimljenih na Kliniku za kirurgiju, ortopediju i
oftalmologiju zbog traume ili zahvata u trbušnoj šupljini, kod kojih su primijeceni simptomi
SSUO-a. Svi podaci prikupljeni su u vremenskom razdoblju od 14.8.2013. do 17.8.2015.
SSUO je dijagnosticiran na temelju zadovoljenja najmanje dva od cetiri potrebna kriterija:
hipotermija ili hipertermija, tahikardija, tahipneja, leukopenija ili leukocitoza ili pojava
nesegmentiranih neutrofila u krvotoku. Svim psima uzeta je krv za hematološku pretragu, a
polovici i za biokemijsku. Svi psi praceni su klinicki za vrijeme hospitalizacije.
Usporedene su vrijednosti trijasa, hematološki i biokemijski nalazi. Istraživanje je pokazalo
da je najucestaliji pokazatelj SSUO-a leukocitoza, a potom tahipneja. Medutim nije pronadena
poveznica izmedu pojedinog pokazatelja i letalnog ishoda. Takoder nije pronadena poveznica
izmedu broja utvrdenih pokazatelja i letalnog ishoda. Utvrdena je znatno veca stopa
preživljavanja nego u drugim istraživanjima.
S obzirom na varijabilnost kriterija te nepouzdanost pokazatelja SSUO-a u pasa, potrebna
su daljnja istraživanja kojima bi se utvrdili dijagnosticki i prognosticki znacajniji pokazatelji.

Abstract (english)

Systemic inflammatory response syndrome (SIRS) is a clinical manifestation of systemic
inflammation induced by various causes. Some of the most common include sepsis, trauma,
burns and neoplasia. This syndrome is often related to increased morbidity and mortality in
animals. This research included ten dogs that developed signs of SIRS and that were
admissioned at the Clinic for surgery, orthopedics and ophthalmology, because of trauma or
they needed surgical intervention in the abdominal cavity. All the data was collected in the
time period from August 14th 2013 until August 17th 2015. SIRS was diagnosed based on
fulfillment of at least two out of four following criteria: hypo- or hyperthermia, tachycardia,
tachypnea, leukocytosis or leukopenia or a left shift. The blood samples were collected from
all ten dogs for hematological analysis, and from five dogs for serum biochemistry analysis.
All of the dogs were re-evaluated clinically during hospitalization.
We compared clinical, hematological and serum biochemistry data. This research showed
that the most frequent SIRS parameter was leukocytosis, followed by tachypnea. However,
there was no link found between certain SIRS parameter and a lethal outcome. Neither was
there a link found between the number of occurring parameters and a lethal outcome. A much
higher survival rate was observed in this research than in other researches.
Considering variability of the SIRS criteria and its unreliability in dogs, further research
ought to be conducted to determine diagnostically and prognostically relevant factors.

• Keywords: sindrom sustavnog upalnog odgovora (SSUO); sepsa; leukocitoza; psi
• Keywords (english): systemic inflammatory response syndrome (SIRS); sepsis; leukocytosis; dogs
• Language: croatian
• URN:NBN: urn:nbn:hr:178:054213
• Study programme: Title: Veterinary Medicine; Study programme type: university; Study level: integrated undergraduate and graduate; Academic / professional title: doktor/doktorica veterinarske medicine (doktor/doktorica veterinarske medicine)
• Type of resource: Text
• File origin: Born digital
• Access conditions: Access restricted to students and staff of home institution
• Created on: 2016-01-12 09:00:10