Pregled kazuistike tumora mliječne žlijezde kuja na Klinici za porodništvo i reprodukciju Veterinarskog fakulteta u razdoblju od 2016. do 2018. godine

master's thesis

• Title (english): Review of Mammary Gland Tumor Casuistic at the Clinic for Obstetrics and Reproduction, Faculty of Veterinary Medicine, in Period Between 2016 and 2018
• Author: Katarina Marjanović
• Mentor: Silvijo Vince (mentor)
• Mentor: Ivan Folnožić (mentor)
• Committee member: Branimira Špoljarić (predsjednik povjerenstva)
• Committee member: Silvijo Vince (član povjerenstva)
• Committee member: Ivan Folnožić (član povjerenstva)
• Granter: University of Zagreb; Faculty of Veterinary Medicine; (Reproduction and Obstetrics Clinic); Zagreb
• Defense date and country: 2019-10-18, Croatia
• Scientific / art field, discipline and subdiscipline: BIOMEDICINE AND HEALTHCARE; Veterinary Medicine; Veterinary Clinical Sciences

Abstract

Tumori mliječnih žlijezda jedna su od najčešćih neoplazmi u kuja. Mogu biti benigni i
maligni, ali benigni mogu maligno alterirati. Maligni tumori imaju lošiju prognozu zbog veće
mogućnosti recidiva i pojave metastaza. Histopatološka analiza i stupanj malignosti bitno
utječu na odabir metode liječenja i prognozu. Cilj ovog istraživanja bio je istražiti pojavnost
tumora mliječne žlijezde u kuja zaprimljenih na Kliniku za porodništvo i reprodukciju
Veterinarskog fakulteta kako bi se utvrdile karakteristike tumora s obzirom na dob, pasminu,
vrijednosti hematoloških i biokemijskih pokazatelja, veličinu, tip i stupanj malignosti tumora.
U istraživanju su obrađeni arhivski podaci prikupljeni za vrijeme redovnog kliničkog
rada Klinike za porodništvo i reprodukciju Veterinarskog fakulteta Sveučilišta u Zagrebu u
razdoblju od 2016. do 2018. godine. Analizirani podaci uključivali su pasminu životinje, dob,
trijas, hematološke i biokemijske parametre krvi, prisutnost metastatskih promjena, veličinu i
pomičnost tumora, histopatološku dijagnozu i stupanj malignosti.
U našem istraživanju prosječna dob prilikom zaprimanja na kliničku obradu bila je 10,5
godina, a 30% pacijenata činile su kuje križanih pasmina. Postotak malignih tumora mliječne
žlijezde iznosio je 87,8%, a najčešće su bili prisutni na kaudalnoj abdominalnoj (27,7%) i
ingvinalnoj mliječnoj žlijezdi (39%). Udio tumora stupnja malignosti I iznosio je 33,9%,
stupnja malignosti II 46,8%, a stupnja malignosti III 19,3% čiji je udio bio najveći u onih tumora
iznad 5 cm promjera. Isto tako, veći udio tumora III stupnja malignosti utvrđen je u
inflamiranih, ulceriranih i u tumora sa zahvaćenim limfnim čvorom. Udio nesegmentiranih
neutrofila bio je povišen u 53% kuja, a C-reaktivni protein u 41,2% slučajeva. Posebno su ove
vrijednosti bile povišene u inflamiranih i ulceriranih tumora.
Rezultati ovog istraživanja potvrđuju nam da su tumori mliječnih žlijezda jedan od
glavnih zdravstvenih problema kuja, osobito u manjih pasmina i kuja starije dobi. Na temelju
istraživanja možemo zaključiti da veličina tumora, inflamiranost, zahvaćenost limfnog čvora i
ulceracije na površini tumora značajno utječu na stupanj malignosti i važan su prognostički
pokazatelj.

Abstract (english)

Mammary gland tumors are one of the most common neoplasms in bitches. They can
be both, benign and malignant, but benign can alter into malignant. Malignant tumors have a
poorer prognosis due to a greater chance of recidivism and the metastasis occurrence.
Histopathological analysis and the degree of malignancy significantly influence the choice of
treatment method and prognosis. The aim of this study was to investigate the incidence of
mammary gland tumors in bitches presented at the Clinic of Obstetrics and Reproduction,
Faculty of Veterinary Medicine, Zagreb and to determine tumor characteristics according to
age, breed, values of hematological and biochemical parameters, size, type and degree of
malignancy of the tumor.
The research processed archival data collected during the regular clinical work of the
Clinic of Obstetrics and Reproduction, Faculty of Veterinary Medicine, University of Zagreb,
from 2016 to 2018. The data analyzed included the breed of animal, age, trias, hematological
and biochemical parameters of blood, presence of metastatic changes, size and motility of the
tumor, histopathological diagnosis and degree of malignancy.
In our study, the average age was 10.5 years and 30% of patients were cross-breed bitches. The
percentage of malignant mammary tumors was 87.8%, most commonly present in the caudal
abdominal (27.7%) and inguinal mammary gland (39%). The proportion of tumors of
malignancy degree I was 33.9%, II 46.8%, and III 19.3% . Degree of malignancy III was highest
in tumors above 5 cm in diameter. A higher proportion of grade III tumors were found in
inflammatory, ulcerated and tumors with affected lymph nodes. The proportion of nonsegmented
neutrophils was increased in 53% of bitches, and the C-reactive protein in 41.2% of
cases. In particular, these values were elevated in inflammatory and ulcerated tumors.
The results of this study confirm that mammary tumors are one of the major health problems in
bitches, especially in small breeds and in older bitches. Based on the research, we can conclude
that the size of the tumor, inflammation, involvement of the lymph node and ulceration on the
tumor surface significantly influence the degree of malignancy and are important prognostic
indicators.

• Keywords: kuje; tumori mliječnih žlijezda; stupanj malignosti; metastaze
• Keywords (english): bitches; mammary gland tumors; degree of malignancy; metastasis
• Language: croatian
• URN:NBN: urn:nbn:hr:178:000990
• Study programme: Title: Veterinary Medicine; Study programme type: university; Study level: integrated undergraduate and graduate; Academic / professional title: doktor/doktorica veterinarske medicine (doktor/doktorica veterinarske medicine)
• Type of resource: Text
• File origin: Born digital
• Access conditions: Open access
• Created on: 2020-11-09 12:54:35