Primjena bioloških lijekova u veterinarskoj medicini

master's thesis

• Title (english): The Use of Biological Medicines in Veterinary Medicine
• Author: Martina Kramarić
• Mentor: Jelena Šuran (mentor)
• Mentor: Josipa Vlainić (komentor)
• Committee member: Frane Božić (predsjednik povjerenstva)
• Committee member: Josipa Vlainić (član povjerenstva)
• Committee member: Andreja Prevendar-Crnić (član povjerenstva)
• Granter: University of Zagreb; Faculty of Veterinary Medicine; (Department of Pharmacology and Toxicology); Zagreb
• Defense date and country: 2019-11-29, Croatia
• Scientific / art field, discipline and subdiscipline: BIOMEDICINE AND HEALTHCARE; Veterinary Medicine; Veterinary Public Health and Food Safety

Abstract

Biološki lijekovi su proteini dobiveni iz ţive stanice, za razliku od „klasiĉnih“ lijekova koji su kemijski sintetizirane male molekule. Posljednjih desetljeća je, zahvaljujući napretku biotehnologije, primjena bioloških lijekova donijela znaĉajna poboljšanja u terapiji kroniĉnih i malignih bolesti ljudi. Skupine proteina koje se koriste u biološkoj terapiji su terapijska protutijela, fuzijski proteini i hormoni. U veterinarskoj medicini je broj odobrenih bioloških lijekova trenutno vrlo ograniĉen, no to će se s vremenom promijeniti. Naime, u svijetu postoji nekoliko farmaceutskih kompanija koje se bave kliniĉkim istraţivanjem primjene biološke terapije u veterinarskoj medicini (maloj praksi), a ona se odnose na primjenu terapijskih protutijela u stanjima kroniĉne boli i upale, imunologije i kod alergija. Obzirom na ulaganja i interes industrije, oĉito je da primjena bioloških lijekova u maloj praksi predstavlja budućnost veterinarske medicine.

Abstract (english)

Biological remedies are proteins derived from living cell, unlike „classic“ drugs that are chemically synthesized by small molecules. Over the last decades, due to the advancement of biotechnology, the use of biological drugs has brought significant improvements in the treatment of chronic and malignant diseases of humans. Protein groups used in biological therapy include therapeutic antibodies, fusion proteins and hormones. In veterinary medicine, the number of approved biological drugs is very limited, but this will change over time. In fact, there are several pharmaceutical companies in the world deal with clinical trials of biological therapy in veterinary medicine (small practice), relating to the use of therapeutic antibodies in conditions of chronic pain and inflammation, immunology and allergies, as well as investment and industry interest, it is obvious the use of biological drug in small practice is the future of veterinary medicine.

• Keywords: biološki lijekovi; imunoterapija; imunologija; alergije; upala
• Keywords (english): biological drugs; immunotherapy; immunology; allergies; inflammation
• Language: croatian
• URN:NBN: urn:nbn:hr:178:291730
• Study programme: Title: Veterinary Medicine; Study programme type: university; Study level: integrated undergraduate and graduate; Academic / professional title: doktor/doktorica veterinarske medicine (doktor/doktorica veterinarske medicine)
• Type of resource: Text
• File origin: Born digital
• Access conditions: Open access
• Created on: 2020-11-11 11:16:53