Dijagnostika i liječenje mastocitoma u pasa

master's thesis

• Title (english): Diagnosis and Treatment of Mast Cell Tumors in Dogs
• Author: Filip Pek
• Mentor: Nada Kučer (mentor)
• Committee member: Mirna Brkljačić (predsjednik povjerenstva)
• Committee member: Ivica Harapin (član povjerenstva)
• Committee member: Nada Kučer (član povjerenstva)
• Granter: University of Zagreb; Faculty of Veterinary Medicine; (Internal Diseases Clinic); Zagreb
• Defense date and country: 2020-10-08, Croatia
• Scientific / art field, discipline and subdiscipline: BIOMEDICINE AND HEALTHCARE; Veterinary Medicine; Veterinary Clinical Sciences

Abstract

Mastocitomi su jedni od najčešćih tumora kože i potkožja pasa, a njihovo biološko ponašanje varira. Većina pacijenata s mastocitnim tumorima uspješno se liječi kirurški, dok liječenje u poodmakloj fazi bolesti zahtijeva multimodalni pristup. Kemoterapija se najčešće koristi kod pacijenata kod kojih je utvrđen mastocitom visokog stupnja malignosti odnosno kod mastocitoma koji imaju visok rizik od metastaziranja. Najčešće korišteni kemoterapijski lijekovi su vinblastin, prednizolon i lomustin. U posljednjih nekoliko godina razvijeni su lijekovi koji inhibiraju receptor tirozin kinazu te su se pokazali kao dobra kemoterapija u liječenju mastocitoma. Nedavna istraživanja o učinku tigilanol tiglata kao lijeka primijenjenog intratumorski pokazuje zadovoljavajuće rezultate u terapiji neoperabilnih mastocitoma. Cilj brige o pacijentima oboljelim od mastocitoma, kao i od drugih malignih bolesti, je održati kvalitetu života na prihvatljivoj razini unatoč bolesti i neizbježnim toksičnim učincima liječenja.

Abstract (english)

Mast cell tumors are among the most common tumors of dermis and subcutaneous tissues in dogs, and their biological behavior varies. Most patients with mast cell tumors undergo successful surgical treatment, while treatment of patients in advanced phases of the disease requires multimodal approach. Chemotherapy is mostly used in patients with of high grade mast cell tumors and those with high risk of metastasizing. Chemotherapy most often includes vinblastine, prednisolone and lomustine. In the last couple of years medications have been developed that inhibit receptor tyrosine kinase, and have proven to be successful in treating mast cell tumors. Recent research on the effects of intratumoral administration of tigilanol tiglate show satisfying results in therapy of inoperable mast cell tumors. The goal of patient care in cases of mast cell tumors, as well as with other malignant tumor, is maintaining of life quality at acceptable level despite effects of the disease and adverse effects of the therapy.

• Keywords: mastocitom; tumor; pas; liječenje; kemoterapija
• Keywords (english): mast cell tumors; tumor; dog; treatment; chemotherapy
• Language: croatian
• URN:NBN: urn:nbn:hr:178:410413
• Study programme: Title: Veterinary Medicine; Study programme type: university; Study level: integrated undergraduate and graduate; Academic / professional title: doktor/doktorica veterinarske medicine (doktor/doktorica veterinarske medicine)
• Type of resource: Text
• File origin: Born digital
• Access conditions: Open access
• Created on: 2020-12-09 17:55:04