Tumori mliječne žlijezde mačaka

master's thesis

• Title (english): Mammary Gland Tumors in Cats
• Author: Dubravka Leventić
• Mentor: Nino Maćešić (mentor)
• Mentor: Tugomir Karadjole (mentor)
• Committee member: Goran Bačić
• Committee member: Nino Maćešić
• Committee member: Tugomir Karadjole
• Granter: University of Zagreb; Faculty of Veterinary Medicine; (Reproduction and Obstetrics Clinic); Zagreb
• Defense date and country: 2014-10-07, Croatia
• Scientific / art field, discipline and subdiscipline: BIOMEDICINE AND HEALTHCARE; Veterinary Medicine; Veterinary Clinical Sciences

Abstract

Tumori mliječne žlijezde, uz mastitis su najvažnija bolest mliječne žlijezde. Neoplazije mliječne žlijezde u mačaka na trećem su mjestu po učestalosti. Rizični faktori za nastanak tumora mliječne žlijezde kod mačke su dob životinje, pasmina i hormonski utjecaj. Oko 80 do 90% tumora mliječne žlijezde su maligni, adenokarcinomi u najvećem postotku. Iznimno su agresivni jer rapidno rastu i metastaziraju u regionalne limfne čvorove, pluća, jetru i slezenu te su najčešće fatalnog završetka. Kod većine mačaka nakon operacije razvit će se recidivi i uginut će unutar jedne godine. Najvažniji prognostički faktori u procjeni vremena bez znakova bolesti i vremena preživljavanja nakon operacije su veličina odnosno obujam tumora i tip operacije. Što je nodul u trenutku operacije manji, to je postoperativna prognoza bolja. Pretpostavlja se da spolni hormoni imaju ulogu u razvoju tumora mliječne žlijezde, jer većina tih tumora javlja se kod ženki, rana ovariektomija značajno smanjuje rizik od razvoja takvih tumora te primjena sintetičkih progestina povećava rizik. Radikalna jednostrana ili obostrana mastektomija je preporuča kirurška metoda za liječenje malignih tumora mliječne žlijezde mačke jer značajno smanjuje vjerojatnost lokalnih recidiva. Kombinacija operativnog zahvata i kemoterapije pruža puno bolju prognozu nego samo operativni zahvat.

Abstract (english)

Mammary tumors, with mastitis are the most important disease of the mammary glands. Neoplasia of the mammary glands in cats are in the third place in frequency. Risk factors for the development of mammary tumors in cats are animals age, breed and hormonal influence. Approximately 80 to 90% of mammary tumors are malignant, adenocarcinomas in the highest percentage. They are extremely aggressive as rapidly grow and metastasize to regional lymph nodes, lungs, liver and spleen, and are usually fatal ending. For most cats after surgery will develop a recurrence and will die within a year. The most important prognostic factors in estimating the time with no signs of disease and survival time after the operation is the size or volume of the tumor and the type of surgery. What is a nodule at the time of surgery less, it is better postoperative forecast. It is assumed that sex hormones play a role in the development of mammary tumors, because the majority of these tumors occur in the female, early ovariectomy significantly reduces the risk of development of such tumors and the use of synthetic progestins increases the risk. Radical unilateral or bilateral mastectomy was recommended surgical method for the treatment of malignant tumors of the mammary glands cat because it significantly reduces the likelihood of local recurrence. The combination of surgery and chemotherapy provides a much better prognosis than just surgery.

• Keywords: mačka; mastektomija; metastaze; rizični faktori; tumor mliječne žlijezde
• Keywords (english): cat; mastectomy; metastases; risk factors; tumor mammary glands
• Language: croatian
• URN:NBN: urn:nbn:hr:178:540896
• Study programme: Title: Veterinary Medicine; Study programme type: university; Study level: integrated undergraduate and graduate; Academic / professional title: doktor/doktorica veterinarske medicine (doktor/doktorica veterinarske medicine)
• Type of resource: Text
• File origin: Born digital
• Access conditions: Access restricted to students and staff of home institution
• Created on: 2016-01-12 12:48:40