Laboratorijska dijagnostika poremećaja hemostaze

master's thesis

• Title (english): Laboratory Diagnostics of Hemostatic Disorders
• Author: Ana Varjačić
• Mentor: Renata Barić Rafaj (mentor)
• Committee member: Iva Šmit (predsjednik povjerenstva)
• Committee member: Luka Krstulović (član povjerenstva)
• Committee member: Renata Barić Rafaj (član povjerenstva)
• Granter: University of Zagreb; Faculty of Veterinary Medicine; (Department of Chemistry and Biochemistry); Zagreb
• Defense date and country: 2018-12-21, Croatia
• Scientific / art field, discipline and subdiscipline: BIOMEDICINE AND HEALTHCARE; Veterinary Medicine; Basic and Preclinical Veterinary Sciences

Abstract

Ovaj rad bavi se procesom hemostaze, poremećajima hemostaze i testovima za detekciju poremećaja pojedinih faza hemostaze u nekoliko poglavlja.
Uvod opisuje ulogu pojedinih činitelja u procesu hemostaze. Hemostaza je kompleksan proces koji uključuje vremenski i prostorno regulirane interakcije između stijenke krvnih žila i cirkulirajućih trombocita, tkivnog faktora povezanog s membranom te prokoagulantnih, antikoagulantnih i fibrinolitičkih plazmatskih proteina. Cilj ovog rada je navesti i opisati moguće korake koje kliničar može učiniti da dođe do dijagnoze kod pacijenata s pojavom spontanog krvarenja, kako bi pacijent postigao potpun oporavak. Rasprava se detaljnije bavi poremećajima triju faza hemostaze, gdje za poremećaje svake faze postoje dostupni laboratorijski testovi koji mogu biti presudni u donošenju valjane dijagnoze i pristupanju ciljanoj terapiji bolesti zgrušavanja krvi kod domaćih životinja, ponajprije kućnih ljubimaca.
Stoga, ovaj rad izdvaja i opisuje korisne laboratorijske testove za detekciju poremećaja pojedinih faza hemostaze, ali se stavlja naglasak i na važnost općeg kliničkog pregleda te iskustva doktora veterinarske medicine u prepoznavanju znakova poremećaja prije izvođenja pojedinih testova.
Zaključak diplomskog rada donosi osvrt na rad u cjelini.

Abstract (english)

This thesis discusses the process of hemostasis, hemostatic disorders and various tests for detection of the disorders of each phase of hemostasis, which is summarized in few chapters.
The introduction discusses the roll of each participant in the hemostatic process. Hemostasis is a complex process which includes timely and spatially regulated interactions between the walls of the blood vessels, circulating platelets, membrane associated tissue factor and procoagulant, anticoagulant and fibrinolytic plasma proteins. The aim of this thesis is to list and describe possible steps which every clinician can make to accurately diagnose patients with the occurance of spontaneous bleeding, to help the patient to achieve full recovery. The discussion interprets the three phases of hemostasis in detail, connecting each phase to adequate laboratory diagnostic tests available for the conformation of the suspected disorders, because these tests may be crucial for correctly diagnosing and treating bleeding disorders in domestic animals, small animals respectively.
Hence, this thesis describes useful methods of laboratory testing for the detection of the hemostatic disorders, each used for the disorders of one of the three phases of hemostasis, but emphesises the importance of the clinical examination and every clinical practitioner’s experience in recognizing the signs of bleeding disorders, before assessing diagnostic testing.
The thesis conclusion summarizes key points of the thesis.

• Keywords: laboratorijska dijagnostika; hemostaza; fibrinoliza
• Keywords (english): laboratory diagnostics; hemostasis; fibrinolysis
• Language: croatian
• URN:NBN: urn:nbn:hr:178:080238
• Study programme: Title: Veterinary Medicine; Study programme type: university; Study level: integrated undergraduate and graduate; Academic / professional title: doktor/doktorica veterinarske medicine (doktor/doktorica veterinarske medicine)
• Type of resource: Text
• File origin: Born digital
• Access conditions: Open access
• Created on: 2020-12-09 19:55:33