Estrogeno djelovanje zearalenona u farmskih životinja

master's thesis

• Title (english): Oestrogenic Effects of Zearalenone in Farm Animals
• Author: Ana Jeličić
• Mentor: Marko Samardžija (mentor)
• Mentor: Jelka Pleadin (mentor)
• Committee member: Ivan Folnožić (predsjednik povjerenstva)
• Committee member: Marko Samardžija (član povjerenstva)
• Committee member: Jelka Pleadin (član povjerenstva)
• Granter: University of Zagreb; Faculty of Veterinary Medicine; (Reproduction and Obstetrics Clinic); Zagreb
• Defense date and country: 2017-01-27, Croatia
• Scientific / art field, discipline and subdiscipline: BIOMEDICINE AND HEALTHCARE; Veterinary Medicine

Abstract

Žitarice i proizvodi od žitarica su u ishrani životinja, kao i u ljudskoj prehrani, među najzastupljenijim komponentama, a ujedno i vrlo pogodna sirovina za razvoj plijesni koje tvore mikotoksine. Značajan problem predstavlja mogućnost prijenosa mikotoksina i njihovih metabolita na ljude, putem jestivih životinjskih proizvoda. Postoji više od 300 izoliranih mikotoksina. Istraživanja se uglavnom odnose na one koji mogu narušiti zdravlje ljudi, domaćih konzumnih životinja, konja i kućnih ljubimaca, kao što su: aflatoksin B1 (AFB1), okarotoksin A (OTA), T-2 toksin, deoksinivalenol (DON), diacetoksiscirpenol (DAS), zearalenon (ZEN), fumonizin (F), patulin (PAT), tremorgene toksine te ergot alkaloide. Zearalenon je mikotoksin, metabolit plijesni iz roda Fusarium koji je po svojoj kemijskoj strukturi sličan estrogenim hormonima. Estrogeno djelovanje zearalenona dovodi do poremećaja urogenitalnog sustava, dok jača akutna ili kronična otrovanja mogu uzrokovati trajne posljedice na organima reproduktivnog sustava, kao što su degenerativne promjena testisa, atrofije jajnika, sterilitet te pobačaje. Kontaminacija hrane životinjskog podrijetla (primarno mlijeka i mesa) fuzarijskim mikotoksinima je niska ukoliko su farmske životinje unosile hranu kontaminiranu ovim mikotoksinima., stoga ove namirnice ne predstavljaju značajnu opasnost za zdravlje ljudi, Kako bi se izbjegli negativni učinci fuzarijskih mikotoksina na zdravlje ljudi neophodna je sustavna kontrola mikotoksina u hrani i hrani za životinje.

Abstract (english)

Grains and grain products in animal diets, as well as in human consumption, are among the most frequently present components, but also very suitable as cultural medium for development of moulds producing mycotoxins. Transfer of mycotoxins and their metabolites via edible animal products to humans represents a significant problem. There are more than 300 isolated mycotoxins. Investigations are mainly focused on those that may harm human health, food animals, horses and pets, such as: aflatoxin B1 (AFB1), okhratoxin A (OTA), T-2 toxin, deoxynivalenol (DON), diacetoxscirpenol (DAS), zearalenone (ZEN), fumonisin (F), patulin (PAT), tremorgenic toxins and ergot alkaloids. Zearalenon is mycotoxin, mould metabolite from Fusarium genus which is chemically similar to oestrogen hormones. Oestrogenic activity of zearalenone leads to urogenital disorders, while stronger acute or chronic poisonings may cause permanent consequences on organs of the reproductive system such as degenerative testicle changes, ovarian atrophies, sterility and abortions. Contamination of food of animal origin (primarily milk and meat) Fusarium mycotoxins is low if the farm animals were fed with feed containing these mycotoxins, and thus these foodstuffs do not represent a significant danger to human health. To avoid negative effects of the Fusarium mycotoxins on human health the systematic control of mycotoxins in food as well as in animal feed is essential.

• Keywords: žitarice; zearalenon; kontaminacija; mikotoksini
• Keywords (english): grains; zearalenon; contamination; mycotoxins
• Language: croatian
• URN:NBN: urn:nbn:hr:178:284893
• Study programme: Title: Veterinary Medicine; Study programme type: university; Study level: integrated undergraduate and graduate; Academic / professional title: doktor/doktorica veterinarske medicine (doktor/doktorica veterinarske medicine)
• Type of resource: Text
• File origin: Born digital
• Access conditions: Open access
• Created on: 2018-07-25 06:10:56